Leukemia inhibitory factor gene is associated with schizophrenia and working memory function
نویسندگان
چکیده
منابع مشابه
Verbal Memory and Working Memory Impairment in Healthy Siblings of Patients with Schizophrenia
Objective: This study aimed to investigate the verbal memory and working memory impairment in healthy siblings of patients with schizophrenia. Methods: The purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. A total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the pat...
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BACKGROUND/AIM Tubal pregnancy is a major cause of maternal death in the first trimester and exploration of its underlying molecular mechanism is of great importance. This study aimed to explore the association of tubal pregnancy with leukemia inhibitory factor (LIF) and leukemia inhibitory factor receptor (LIFR) expression in oviduct tissues. MATERIALS AND METHODS Immunohistochemistry was pe...
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Background: Interaction between killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen (HLA) class I molecules is important for regulation of natural killer (NK) cell function. Objective: The aim of this study was to investigate the impact of compound KIR-HLA genotype on susceptibility to acute leukemia. Methods: Cohorts of Iranian patients with acute myeloid leukemia (AML;...
متن کاملImpaired suppression of delay-period alpha and beta is associated with impaired working memory in schizophrenia.
BACKGROUND Although people with schizophrenia (PSZ) frequently exhibit reduced working memory capacity relative to healthy comparison subjects (HCS), the mechanisms that underlie this impairment are not yet known. The present study aimed to assess one putative mechanism: impaired suppression of alpha and beta frequency bands during the delay period of a visual working memory task. METHODS The...
متن کاملSchizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition.
Schizophrenia is associated with severe cognitive deficits, including impaired working memory (WM). A neural mechanism that may contribute to WM impairment is the disruption in excitation-inhibition (E/I) balance in cortical microcircuits. It remains unknown, however, how these alterations map onto quantifiable behavioral deficits in patients. Based on predictions from a validated microcircuit ...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2010
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2009.10.020